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This research was performed in accordance with the Declaration of Helsinki principles, approved by the Ethics Committee of the TBZMED (ethics-code: IR.TBZMED.REC.1396.747), and registered with the Iranian-Registry-of-Clinical-Trials ( id: IRCT20080904001197N13)

It is not approved for human or animal use and should only be handled by qualified researchers in appropriate laboratory settings

This review was supported by intramural GRASP award 2190268 from LLU