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It can also reverse the harmful effects of a high-fat diet on liver metabolic pathways and related regulators, such as ACOX, SCAP, SREBF, PPARGC1B, and INSR (91)

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2.2.3 Key regulatory networks The tumor suppressor p53 can transcriptionally repress SLC7A11 expression, diminishing cystine uptake, curtailing GSH synthesis, and thereby promoting ferroptosis ( Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating redox homeostasis

Lastly, obesity is a risk factor for venous thromboembolism (VTE)

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