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By examining clinical trial data and patient reports, we can get a clearer picture of how often this side effect occurs

Currently, some countries are considering to ban it entirely (like Denmark) and the permitted use level is very low (under 0.01%)

10.1177/00220345221100179 [DOI] [PubMed] [Google Scholar] 84.Chen, Y

Unlike thiazolidinediones (such as pioglitazone), which activate peroxisome proliferator-activated receptors and directly promote sodium and water retention, tirzepatide's receptor targets do not have this established effect

Meanwhile, a process called adaptive thermogenesis kicks in, where your body becomes slightly more efficient at using calories, burning fewer than predicted by weight alone