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Though both act on the incretin system, they represent distinctly different generations of peptide engineering semaglutide as a refined single-receptor GLP-1 agonist, and tirzepatide as a dual GLP-1/GIP receptor agonist

In addition to glutathione, this complex includes bioavailable B vitamins to optimize energy levels and milk thistle extract to support liver health and proper bile flow

PMID 21131568

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In this trial, tirzepatide at all three doses (5 mg, 10 mg, and 15 mg) achieved significantly greater weight loss compared to once weekly semaglutide 1 mg

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