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A separate 2020 systematic review of PDRN in wound healing and tissue regeneration, drawing on 34 eligible studies, reached the same conclusion about the salvage pathway and A2A receptor activation, and on the clinical side, Squadrito and colleagues ran a randomized, double-blind, placebo-controlled trial of PDRN in chronic diabetic foot ulcers and found meaningfully higher complete-healing rates in the PDRN group