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In response to stress, an intricate molecular mechanism facilitated by sensor cysteines within Keap1 allows Nrf2 to escape ubiquitination, accumulate within the cell, and translocate to the nucleus, where it can promote its antioxidant transcription program

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Before starting B12 supplements , particularly high-dose formulations, discuss with your GP if you have: A history of sleep disorders Existing anxiety or mood disorders Cardiovascular conditions Kidney disease (which may affect B12 metabolism and test interpretation) Leber's hereditary optic neuropathy (cyanocobalamin is contraindicated