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Quickstart Highlights Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH) , the decapeptide that signals the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) [1] [5]

Patients should never stop or adjust their medication without first consulting the prescribing clinician or trial investigator, as abrupt discontinuation may affect metabolic control and overall health outcomes

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TGF- signaling is a key driver of this metabolic shift, upregulating enzymes such as PHGDH, PSAT1, PSPH, and SHMT1/2 that are essential for serineglycine biosynthesis and collagen production [17, 18]