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It suggests that, at low doses, Rot impairs mitochondrial function without initiating cell death mechanisms such as calcium overload or persistent depolarization 6,53,54,55

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None of these agents altered the end-point increase of [Ca 2+ ] i measured in response to JWU-A021 (data not shown)

Common reasons include: Pernicious anemia , an autoimmune condition affecting intrinsic factor production Gastrointestinal disorders, such as Crohns disease or celiac disease Prolonged use of certain medications, like proton pump inhibitors Knowing these causes helps spot at-risk people