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These studies showed that one-third of a subset of classical EDS patients that could be evaluated (because they are heterozygous for polymorphisms of COL5A1 ) did not express the mutant allele

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doi: 10.1001/jama.2020.12839 116 GeorgievaEAnanievJYovchevYArabadzhievGAbrashevHAbrashevaDet al

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Wang R, van Keeken NM, Siddiqui S, Dijksman LM, Maudsley S, Derval D, van Dam PS, Martin B