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Conclusions Carnitine is an important element regulating many various functions in the animal/human body, including transport of activated long-chain fatty acids from the cytosol to the mitochondrial matrix, where -oxidation takes place

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Importantly, RRM2 is often found overexpressed in NB, and its depletion was shown to induce G1/S phase arrest due to replicative stress and checkpoint kinase 1 (CHK1) activation (47, 48)

The activation of PPAR- promotes insulin sensitization and has a role in lipid storage, whereas the activation of PPAR-/ enhances fatty acid metabolism and reveals anti-inflammatory effects by inhibiting inflammatory macrophage phenotypes