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Under normal circumstances this does not occur, since GSH, in conjunction with the enzyme glutathione peroxidase (GSH-Px), rapidly inactivates these compounds

(PubMed) Stone KL, Lui LY, Christen WG, et al

This model was critically reassessed a few years ago by Bachhawat and Yadav, who extended it to include the intracellular degradation of GSH (Figure 1)

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