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A 2020 study found that those with vitamin B12 deficiency may present with cognitive disorder, though the deficiency was not shown to be a direct risk factor for cognitive decline ( However, results have been mixed and treatment with vitamin B12 wasnt effective at improving brain function in people with normal brain function ( Depression Its been suggested that there may be a link between low vitamin B12 levels and depression

When HbA1c is considered unreliable, UK and WHO guidance recommends using fasting plasma glucose or a 75 g oral glucose tolerance test (OGTT) for diabetes diagnosis or assessment, as outlined in WHO 2011 guidance on the use of HbA1c in diabetes diagnosis and reflected in NICE NG28 (Type 2 Diabetes in Adults: Management)

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Andreassen KV, Feigh M, Hjuler ST, Gydesen S, Henriksen JE, Beck-Nielsen H, et al