Crucially, this insulinotropic effect is glucose-dependent, meaning insulin secretion diminishes as blood glucose normalises
Here is the real discussion from people who actually tried it
With the right strategiesgradual dose escalation, dietary modifications, adequate hydration, and when needed, anti-nausea medicationsmost people can successfully manage this side effect and continue benefiting from these powerful medications
Similarly, injecting into warm skin like after a hot shower or following physical activity brings blood vessels closer to the surface, making them easier to damage
Garlic and onions are also excellent sources
In the landmark STEP clinical trial program, semaglutide produced an average weight loss of 14.9% of body weight over 68 weeks a level of efficacy that had previously only been achievable through bariatric surgery