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51,52 In LR, ER stress also affects leptin signaling, blocking the JAK2/STAT3 pathway triggered by leptin present in POMC neurons, potentially contributing to metabolic disturbances in the peripheral tissues of obese phenotypes (Fig

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The benefits are comparable or superior to the benefits of GLP-1 drugs, including dramatic weight loss and secondary long-term health benefits, such as improved blood sugar levels

When combined, these overlapping effects may make gastrointestinal symptoms worse, especially if youre already experiencing side effects with semaglutide

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