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In clinical trials, 86% of non-diabetic patients receiving once-weekly semaglutide injections lost at least 5% of their body weight.[8] Ozempic : Ozempic is a once-weekly subcutaneous injection approved for patients with T2D, though it is sometimes prescribed off-label for weight loss.[9] It is used alongside diet and exercise to improve glycemic control and reduce cardiovascular risk in adults with T2D