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Paietta E, Andreeff M , Papenhausen P, Roberts M, Wiernik PH

Finally, although the majority of the current research on ferroptosis in IDD has focused on disease progression, early intervention may exhibit a greater impact

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Future work should be focused and lean: enroll truly deficient, higher-risk patients, standardize formulations and dosing, and test event-driven hard endpoints aligned to mechanism, while embedding translational markers to confirm on-target biology