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Evaluation of the protective effect of losartan in acetaminophen-induced liver and kidney damage in mice

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The interactions of lipin-1 with PPAR and PGC-1 leads to increased expression of fatty acid oxidizing genes such as carnitine palmitoyltransferase-1 (CPT-1: encoded by the CPT1A gene), acyl-CoA oxidases (peroxisomal fatty acid oxidation pathway), and medium-chain acyl-CoA dehydrogenase (MCAD: encoded by the ACADM gene)

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Melatonin, acting through MT1/MT2 and cytosolic binding sites, modulates both the NF-B and JAK/STAT pathways, curbing inflammatory gene transcription while preserving glucocorticoid sensitivity (221)