While dermatologists are seeing potential benefits of using GLP-1s as part of a comprehensive treatment approach, no therapy is right for everyone. Some of the limitations and risks associated with GLP-1 use include: Side effects many people experience side effects like nausea, vomiting, gallbladder disease, and GI discomfort
Oxidative stress can lead to diabetes, cancer and rheumatoid arthritis
Practical Application Resistance training: 2-3 sessions weekly, improves insulin sensitivity Moderate aerobic exercise: 150+ minutes weekly, reduces inflammation High-intensity intervals: 1-2 sessions weekly, enhances metabolic flexibility Daily movement: Walking, stairs, active living reduces baseline DPP-4 Post-meal walks: 10-15 minutes after eating enhances GLP-1 effects Morning exercise: May optimize DPP-4 patterns throughout the day Consistency over intensity: Regular moderate exercise beats sporadic intense sessions Strategy 5: Sleep Quality and Circadian Rhythm The Science: DPP-4 expression follows circadian rhythms
What is fascinating is that their effects are not limited to alcohol: preclinical and correlational data indicate possible benefits in decreasing use of nicotine and opioids, which makes sense as alcohol, cannabis, opioid, and nicotine use disorders cluster together genetically into one brain disorder
In: Laurent GJ, Shapiro SD (eds) Oxidants and antioxidants, encyclopedia of respiratory medicine, 2006 258266