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To put that into perspective, Ozempic and Wegovy are GLP-1 receptor agonists, while Zepbound and Mounjaro are dual GIP/GLP-1 receptor agonists

The Endocrine Society's 2020 position statement on peptide therapeutics emphasizes that "the absence of Phase I dose-escalation data for novel peptides like BPC-157 means that any dose recommendation is extrapolated, not validated, and clinicians should err on the side of the lowest effective dose" 19

The table classifies semaglutide as a GLP-1 agonist with minimal GIPR activity, while tirzepatide is listed as a dual GLP-1 and GIP agonist with balanced GIPR agonism

Different mechanism

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The goal is not to choose whatever medication is trending